Association between the number of peripheral blood stem cells and cardiac function index in patients with ischemic heart failure / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 491-494, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-236469
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the association between the number of peripheral blood stem cells (PBSC) and cardiac function index (NYHA grade, left ventricular ejection fraction, LVEF, N-terminal-proB-type Natriuretic Peptide, NT-pro BNP) in patients with ischemic heart failure (IHF).</p><p><b>METHODS</b>A total of 199 patients hospitalized in our department between August 2007 and April 2008 due to IHF were included in this study. NYHA grade, LVEF (measured by echocardiography), plasma NT-proBNP and number of PBSC were analyzed.</p><p><b>RESULTS</b>PBSC number was significantly decreased in proportion with increasing NYHA grade and PBSC number was significantly lower in patients with NYHA IV than that with class II and III (all P<0.01). LVEF was positively correlated with PBSC number (r = 0.35, P = 0.001), NT-proBNP was negatively correlated with PBSC number (r = - 0.39, P = 0.009). Multiple regression analysis showed that LVEF and NT-proBNP were major determinants of PBSC (Beta = 0.14, - 0.25, 95% CI = -0.01 - 0.02, -0.18 - -0.04, P<0.05, P<0.01).</p><p><b>CONCLUSION</b>PBSC number was significantly correlated to cardiac function in IHF patients.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Prognosis
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Blood
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Hematopoietic Stem Cells
/
Cell Count
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Regression Analysis
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Myocardial Ischemia
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Ventricular Dysfunction, Left
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Cell Biology
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Heart Failure
Type of study:
Diagnostic study
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Prognostic study
Limits:
Adult
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Aged
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Aged, 80 and over
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2009
Document type:
Article