The clinical characteristics of 5 patients with inherited hypertrophic cardiomyopathy / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 320-323, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-236482
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical characteristics of patients with inherited hypertrophic cardiomyopathy.</p><p><b>METHODS</b>The clinical characteristics, electrocardiogram, serum chemistry and diagnostic methods were retrospectively investigated in 5 patients with inherited hypertrophic cardiomyopathy.</p><p><b>RESULTS</b>The electrocardiograms of all patients were abnormal, with prominent left ventricular voltage and ST-T changes. One male patient with clinicopathological features of early onset, muscle weakness, ventricular preexcitation, elevations of two serum proteins and intracytoplasmic vacuoles containing autophagic material and glycogen in biceps brachial muscle cells was diagnosed Danon's disease. Mitochondrial cardiomyopathy was diagnosed in one male patient with early onset, short PR interval and biopsy findings of ragged-red fibers in biceps brachial muscle. Three patients were diagnosed as Fabry's disease with clinical characteristics including pain and acroparesthesias, angiokeratoma and decrease of alpha-galactosidase A activity.</p><p><b>CONCLUSION</b>Some of the rare inherited hypertrophic cardiomyopathy might easily be clinically misdiagnosed as hypertrophic cardiomyopathy, systemic and careful case history inquiring and specific relevant examinations would help to make the right diagnosis in these patients.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
/
Other circulatory Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Cardiomyopathy, Hypertrophic, Familial
/
Diagnosis
/
Diagnosis, Differential
/
Genetics
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2009
Document type:
Article