Clinical significance of signal transduction and activators of transcription 3, E-cadherin and vimentin in colon cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 202-205, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-237141
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical significance of STAT3, E-cadherin and vimentin in colon cancer.</p><p><b>METHODS</b>Samples of colon cancer tissue and adjacent normal tissue were procured from 70 patients with colon cancer. The expressions of STAT3, E-cadherin and vimentin were detected by immunohistochemistry. Associations of clinicopathological characteristics and these three factors were evaluated.</p><p><b>RESULTS</b>STAT3, E-cadherin, vimentin were positive in 74.3%,32.9%, and 78.6% in the colon cancer tissues, respectively, and were 15.7%, 82.9%, and 12.9% in normal colon mucosa tissues, respectively. They were correlated with tumor differentiation, depth of invasion, lymph node metastasis, and TNM staging(P<0.05). There was a positive correlation between STAT3 and vimentin expression(P<0.01). However, STAT3 was negatively correlated with E-cadherin(P<0.01).</p><p><b>CONCLUSIONS</b>STAT3, E-cadherin and vimentin are closely associated with colon cancer. The expressions of STAT3, E-cadherin and vimentin may serve as prognostic indicators for patients with colon cancer.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Vimentin
/
Cadherins
/
Colonic Neoplasms
/
STAT3 Transcription Factor
/
Metabolism
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Aged, 80 and over
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2011
Document type:
Article