Correlation between mutation of GyrA and ParC genes and quinolone resistance in Neisseria gonorrhoeae / 中华男科学杂志
National Journal of Andrology
; (12): 275-278, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-238046
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the correlation between mutation of GyrA and ParC genes and quinolone resistance in Neisseria Gonorrhoeae.</p><p><b>METHODS</b>The gene fragments of quinolone resistance-determining region (QRDR) in GyrA and ParC genes in 20 Neisseria gonorrhoeae strains clinically isolated in Wuxi, China, were sequenced, and the susceptibility of the 20 strains to quinolone was examined by agar diffusion method.</p><p><b>RESULTS</b>The mutations at the Asp95 point in GyrA gene were found in 20 strains. Of the 19 stains examined, 16 had mutations at the 86, 87, 88, 91 points in ParC genes.</p><p><b>CONCLUSIONS</b>The mutations of Asp95 in GyrA gene and Asp86, Ser87, Ser88, Glu91 in ParC gene contribute to quinolone resistance in Neisseria Gonorrhoeae.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Molecular Sequence Data
/
Base Sequence
/
Quinolones
/
DNA Gyrase
/
DNA Topoisomerase IV
/
Drug Resistance, Bacterial
/
Genetics
/
Mutation
/
Neisseria gonorrhoeae
Limits:
Humans
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2003
Document type:
Article