Cytotoxicity study of heparin coated polyvinyl chloride material / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 739-741, 2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-238352
Responsible library:
WPRO
ABSTRACT
In this study, heparin ionically coated polyvinyl chloride (PVC) material was prepared by heparin-benzalkonium chloride complex (Group A), heparin-benzalkonium bromide complex (Group B) and heparin-polyethyleneimine compound (Group C). Cytotoxicity evaluation was conducted by direct cell contact evaluation and MTT colorimetry method. The results showed Group A and Group B caused L-929 cells to die out while Group C showed good compatibility with cells. The OD levels of Group A and B were lower than that of the Group C in MTT test. Method A and method B of heparin coating had remarkable cytotoxicity, while method C had little cytotoxicity and could be further studied for clinical use.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polyvinyl Chloride
/
Materials Testing
/
Heparin
/
Cells, Cultured
/
Coated Materials, Biocompatible
/
Cell Biology
/
Toxicity
/
Fibroblasts
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2005
Document type:
Article