Monosomal karyotype among adult acute myeloid leukemia: clinical characteristic and prognostic analysis / 中华血液学杂志
Chinese Journal of Hematology
; (12): 393-396, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-238801
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical characteristics and prognostic value of monosomal karyotype (MK) patients in adult acute myeloid leukemia (AML).</p><p><b>METHODS</b>We retrospectively studied 45 patients of MK⁺ in newly-diagnosed adult AML in our center from Oct 2000 to Dec 2012. Clinical characteristics, cytogenetic data and prognostic features were analyzed in the cohort of MK⁺ patients.</p><p><b>RESULTS</b>MK was found in 45 patients (19.0%) of 237 newly-diagnosed adult AML with cytogenetic data available at diagnoses. Among these 45 cases, there were 28 male (62.2%) and 17 female (37.8%). Median age of MK⁺ patients at diagnose was 58(18-91) years old. The presence of -5(31.1%) and -7(17.8%) were the most common chromatid among MK⁺ AML patients. MK was much more prevalent among elderly patients. Among AML patients, the proportions of MK⁺ patients younger than 30, 30 to 59 and older than 60 years old groups were 11.5%, 17.7% and 22.4%, respectively. There was no difference between MK⁺ and MK⁻ patients in gender distribution (P=0.545). There was also no difference between MK⁺ and MK⁻ patients in the distribution of FAB castigation (P=0.239). Median survival of MK⁺ AML patients was 6.5 months. Cumulative 5-year overall survival (OS) of was 5.2%. Forty-three MK⁺ patients (43/45, 95.6%) also had a complex karyotype (CK). Two cases that did not meet the CK had not achieved complete remission (CR), and died within 6 months. There were 12 patients who were CK⁺ in 192 MK⁻ patients. The differences of OS and CR rates between MK⁺CK⁺ patients and MK⁻CK⁺ were statistically significant (P<0.05).</p><p><b>CONCLUSION</b>The increased detection rate of MK with age was associated with lower CR and OS in AML patients.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
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Remission Induction
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Leukemia, Myeloid, Acute
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Retrospective Studies
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Chromosome Aberrations
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Diagnosis
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Genetics
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Karyotyping
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Monosomy
Type of study:
Diagnostic study
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Observational study
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Prognostic study
Limits:
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2014
Document type:
Article