Screening of specific miRNA in early gastric cancer / 中华胃肠外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To examine the micro-RNA (mirna) expression profile in tissues of early gastric cancer and to screen the specific mirna associated with gastric cancer.</p><p><b>METHODS</b>Gene chip technology was used to detect the expression of mirna in early gastric cancer tissues and adjacent normal tissues.</p><p><b>RESULTS</b>Compared to adjacent normal tissues, a total of 36 mirnas were down-regulated, such as mir-9-1, mir-103 and mir-141, while 12 mirnas were up-regulated, such as mir-196a, mir-142-3p and mir-25, etc.</p><p><b>CONCLUSION</b>Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer.</p>