Notch signaling in bone formation and related skeletal diseases / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 274-279, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-239488
Responsible library:
WPRO
ABSTRACT
Notch signaling is highly conserved in evolution and regarded as a key factor in cell fate determination. It mediates cell-to-cell interactions that are critical for embryonic development and tissue renewal, and is involved in the occurrence and metastasis of neoplasm. Recent researches have found that such signaling plays an important role in modulating the differentiation of chondrocytes, osteoblasts and osteoclasts. Dysfunction of Notch signaling can result in many skeletal diseases such as bone tumor, disorders of bone development or bone metabolism.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Osteogenesis
/
Bone and Bones
/
Bone Development
/
Bone Diseases
/
Signal Transduction
/
Cell Biology
/
Receptors, Notch
/
Genetics
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2015
Document type:
Article