Solubilization on cryptotanshinone by hydroxypropyl-beta-cyclodextrin and preparation of their inclusion compound / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1328-1331, 2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-239692
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT.</p><p><b>METHOD</b>Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum.</p><p><b>RESULT</b>Inclusion ratio of CT versus HPCD was 11. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug.</p><p><b>CONCLUSION</b>Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phenanthrenes
/
Solubility
/
Time Factors
/
Drug Carriers
/
Drugs, Chinese Herbal
/
Biological Availability
/
Chemistry
/
Technology, Pharmaceutical
/
Salvia miltiorrhiza
/
Beta-Cyclodextrins
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Document type:
Article