Clinical study of amphotericin B in the treatment of invasive fungal infection in 111 hematological disorder patients with neutrocytopenia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 472-475, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-239993
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the differences in clinical therapeutic effect and safety between amphotericin B and its liposome form in treating invasive fungal infection (IFI) in hematological disorder with neutrocytopenia.</p><p><b>METHODS</b>Of 111 patients with IFI, 82 were treated with amphotericin B and 29 with amphotericin B liposome. The mean cumulative dose of amphotericin B was 617 (60-1895) mg and the mean course was 18 (7-60) d, and those for amphotericin B liposome was 925 (140-3420) mg and 13 (7-50) d, respectively.</p><p><b>RESULTS</b>The total effective rates of amphotericin B and its liposome groups were 69% and 58%, respectively (P>0.05). The adverse effect rates of chill and fever in amphotericin B and its liposome groups were 21% and 10% (P>0.05), hypopotassemia 34% and 14% (P=0.03), hepatic impairment 22% and 17% (P>0.05), and renal impairment 9% and 3%, respectively (P>0.05).</p><p><b>CONCLUSION</b>The therapeutic effect for IFI of amphotericin B and its liposome was similar. The severe adverse reaction of amphotericin B liposome was slightly lower than that of amphotericin B.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Amphotericin B
/
Retrospective Studies
/
Treatment Outcome
/
Therapeutic Uses
/
Agranulocytosis
/
Drug Therapy
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Hematologic Diseases
/
Liposomes
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Mycoses
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Antifungal Agents
Type of study:
Observational study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2008
Document type:
Article