Effect of wenxin capsule on myocyte apoptosis and expression of Bcl-2, Fas gene protein in rats of experimental myocardial ischemia / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 769-771, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-240864
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular mechanism of Wenxin Capsule (WXC, an effective Chinese composite drug) in preventing and treating myocardial ischemia of coronary heart disease.</p><p><b>METHODS</b>Rat model of myocardial ischemia was established by subcutaneous multi-point injecting isoproterenol. Effect of WXC on cell apoptosis was observed by transmission electron microscopy and TUNEL method, and its effect on apoptotic related gene Bcl-2 and Fas gene protein expression was observed by immunohistochemical method.</p><p><b>RESULTS</b>Isoproterenol induced myocardial ischemic injury could cause evident cardial cell apoptosis, obvious enhance Fas gene protein expression and mild enhance Bcl-2 gene protein expression. WXC could significantly down-regulate Fas, up-regulate Bcl-2 gene protein expression, significantly inhibit and block the myocardial cell apoptosis.</p><p><b>CONCLUSIONS</b>To inhibit and block the event of cell apoptosis through regulating Bcl-2 and Fas gene protein expression in ischemic myocardium might be one of the mechanisms of WXT in preventing and treating myocardial ischemic injury of coronary heart disease.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Drugs, Chinese Herbal
/
Rats, Wistar
/
Myocardial Ischemia
/
Apoptosis
/
Fas Receptor
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Proto-Oncogene Proteins c-bcl-2
/
Myocytes, Cardiac
/
Drug Combinations
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2003
Document type:
Article