Synthesis and antibacterial activity of ciprofloxacin derivatives / 药学学报

ABSTRACT

<p><b>AIM</b>To study the synthesis and antibacterial activity of ciprofloxacin derivatives.</p><p><b>METHODS</b>Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested.</p><p><b>RESULTS</b>Nine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis.</p><p><b>CONCLUSION</b>Compounds II, IVC and IVD showed appreciable antibacterial activity, and were worth further studying.</p>