Long-term outcomes and factors for predicting ventricular arrhythmia in patients with catecholaminergic polymorphic ventricular tachycardia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 671-677, 2013.
Article
in Zh
| WPRIM
| ID: wpr-241448
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate factors for predicting ventricular arrhythmia, the clinical effect of drugs on patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), and their long-term outcomes.</p><p><b>METHODS</b>Six patients diagnosed with CPVT underwent a series of electrocardiograms and 24-hour Holter monitoring. β-blockers were recommended for all patients, while some patients were also prescribed propafenone and 1 patient underwent catheter-based renal sympathetic denervation (RDN). The characteristics of electrocardiogram, arrhythmia and long-term outcomes were monitored.</p><p><b>RESULTS</b>Syncope episodes did not occur any longer in 1 patient on β-blocker, but recurred in 3 other patients and 2 patients died (one due to his cessation of metoprolol for 3 months). Inverted and/or bifid T waves and abnormal U wave were observed in the precordial leads. T wave alternans was observed in 4 patients in the precordial leads. These abnormal electrocardiogram features disappeared or diminished with β-blocker treatment. All spontaneous episodes of ventricular tachycardia occurred prior to sinus tachycardia and frequent polymorphic premature ventricular contractions.</p><p><b>CONCLUSIONS</b>Bifid and/or inverted T waves, T wave alternans and abnormal U waves together with sinus tachycardia and frequent premature ventricular contractions are indicator for predicting ventricular arrhythmia and assessing the effect of β-blockers. Compliance with β-blocker treatment is a strong indicator of outcome.</p>
Full text:
1
Database:
WPRIM
Main subject:
Electrocardiography, Ambulatory
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Treatment Outcome
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Tachycardia, Ventricular
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Adrenergic beta-Antagonists
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Therapeutic Uses
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Drug Therapy
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Electrocardiography
Type of study:
Prognostic_studies
Limits:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2013
Document type:
Article