Therapeutic effect of clofarabine in children with relapsed or refractory acute lymphoblastic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 444-447, 2013.
Article
in Zh
| WPRIM
| ID: wpr-241497
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the efficacy and adverse effects of clofarabine for relapsed/refractory acute lymphoblastic leukemia in children.</p><p><b>METHODS</b>Twenty-six pediatric patients with relapsed/refractory acute lymphoblastic leukemia were treated with clofarabine. There were 22 males and 4 females, with a mean age of 9.5 years (ranging from 4 to 17 years). They received clofarabine 52 mg/m2 intravenously over 2 hours daily for 5 days. Thirteen patients received two cycles and one patient received three cycles.</p><p><b>RESULTS</b>In the first cycle of clofarabine, complete remission was obtained in 11 children (42%) and partial remission was obtained in 7 children (27%). Eight children (31%) were considered unresponsive. In the second cycle, 11 (85%) of the 13 children obtained complete remission, 1 (8%) partial remission and 1 (8%) was unresponsive. One child received three cycles and obtained complete remission in each cycle. The common adverse events were myelosuppression, infection, liver dysfunction and gastrointestinal adverse reactions. There were no chemotherapy-related deaths.</p><p><b>CONCLUSIONS</b>Clofarabine is effective in the treatment of children with relapsed/refractory acute lymphoblastic leukemia and its adverse effects can be tolerated. Clofarabine could be a promising new treatment for relapsed/refractory acute lymphoblastic leukemia.</p>
Full text:
1
Database:
WPRIM
Main subject:
Recurrence
/
Arabinonucleosides
/
Adenine Nucleotides
/
Follow-Up Studies
/
Therapeutic Uses
/
Drug Therapy
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Antineoplastic Agents
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
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Child
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Child, preschool
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Female
/
Humans
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Infant
/
Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2013
Document type:
Article