Effect of timing of tracheotomy on clinical outcomes: an update meta-analysis including 11 trials / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 159-166, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-243197
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To estimate the relative effect of early vs. late tracheotomy on clinical end-points in unselected intensive care unit (ICU) patients undergoing mechanical ventilation.</p><p><b>METHODS</b>We searched electronic databases (up to February 27, 2013) for both randomized control trials and observational studies satisfying the predefined inclusion criteria.</p><p><b>RESULTS</b>We retrieved 11 reports of studies including a total of 13 705 patients. Early tracheotomy was associated with significant reductions in mortality [33.3% vs. 36.3%; relative risk (RR); 0.92; 95% confidence interval (CI) 0.88, 0.97; I(2) 29%], length of ICU stay (mean difference -6.55 days; 95% CI -8.19, -4.90; I(2) 98%) and duration of mechanical ventilation (mean difference -6.53 days; 95% CI -11.43, -1.63; I(2) 100%). However, as compared with late tracheotomy, early tracheotomy did not reduce the incidence of hospital pneumonia (21.9% vs. 21.0%, RR 0.85; 95% CI 0.68, 1.06; I(2) 67%).</p><p><b>CONCLUSIONS</b>Early tracheotomy can reduce length of ICU stay, duration of mechanical ventilation and mortality but has no influence on hospital pneumonia when compared with late tracheotomy. Once the decision has been made about tracheotomy, clinical physicians should not hesitate to perform the procedure.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Respiration, Artificial
/
Time Factors
/
Tracheotomy
/
Randomized Controlled Trials as Topic
/
Intensive Care Units
/
Length of Stay
Type of study:
Controlled clinical trial
/
Etiology study
/
Observational study
/
Prognostic study
/
Systematic review
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2013
Document type:
Article