Myocardial involvement in 2494 patients with systemic lupus erythematosus / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 317-319, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-243785
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical characteristics and related pathogenetic factors in systemic lupus erythematosus (SLE) patients with myocardial involvement.</p><p><b>METHODS</b>Clinic data and myocardial involvements were analyzed in 2494 SLE patients who admitted to our hospital from 1997 to 2007.</p><p><b>RESULTS</b>Myocardial involvements were seen in 13 out of 2494 SLE patients (0.52%). Dyspnea of various degrees and left ventricular systolic dysfunction are frequently found in these patients with myocardial involvements. Glucocorticoid therapy significantly increased left ventricular ejection fraction (LVEF, 37.7% +/- 5.8% vs. 40.9% +/- 7.1%, P = 0.002). Significant associations were found between anti-rRNP antibody and LVEF (r = 0.843, P = 0.001) as well as between cardiac troponin I (cTnI) and left ventricular end diastolic diameter (LVEDD) (r = 0.656, P = 0.036).</p><p><b>CONCLUSIONS</b>Myocardium is rarely affected in patients with SLE in this cohort. Echocardiography is a valuable method for detecting cardiac abnormalities in patients with SLE. Glucocorticoid therapy could improve cardiac function in SLE patients with cardiac involvement and serological factors are related to cardiac functions.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
/
Immune Disorders
/
Musculoskeletal Diseases and Rheumatic Disorders
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Therapeutics
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Therapeutic Uses
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Diagnosis
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Glucocorticoids
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Lupus Erythematosus, Systemic
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Cardiomyopathies
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Myocardium
Type of study:
Diagnostic study
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Prognostic study
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2008
Document type:
Article