Study of the association between HLA-DQA1 alleles and environmental factors in psoriasis / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 445-448, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-244247
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study of the HLA-DQA(1) alleles and environment interaction in type I psoriasis.</p><p><b>METHODS</b>Using case-control study, 144 type I psoriatics and 273 healthy people were investigated. The HLA-DQA(1) alleles were examined by PCR-SSP.</p><p><b>RESULTS</b>(1) HLA-DQA(1)*0104 and DQA(1)*0201 alleles were positively associated with type I psoriasis (P(c) < 0.002); HLA-DQA(1)*0501 allele was negatively associated with type I psoriasis (P(c) < 0.000 5). (2) The HLA-DQA(1)*0104 allele and moisture was interaction in type I psoriasis (P = 0.023 8, OR = 5.29). (3) There were no interactions between the HLA-DQA(1)*0201 allele and 10 environmental factors in type I psoriasis. (4) The HLA-DQA(1)*0501 allele, moisture (P = 0.002 4, OR = 7.50), eating fish and shrimp (P = 0.000 4, OR = 12.92), drugs (P = 0.043 3, OR = 9.43) or vaccination (P = 0.043 3, OR = 9.43) were interacted in type I psoriasis.</p><p><b>CONCLUSIONS</b>(1) HLA-DQA(1)*0104 and DQA(1)*0201 alleles might be the susceptible genes or it may have close linkage with the susceptible gene. HLA-DQA(1)*0501 allele had protective effect against the development of type I psoriasis. (2) The HLA-DQA(1)*0104 and DQA(1)*0501 alleles increased risk possibility of environmental factors in type I psoriasis.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Database:
WPRIM (Western Pacific)
Main subject:
Psoriasis
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HLA-DQ Antigens
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Case-Control Studies
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Alleles
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Environment
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Allergy and Immunology
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HLA-DQ alpha-Chains
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Genetics
Type of study:
Observational study
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Risk factors
Limits:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2002
Document type:
Article