A linkage disequilibrium study of methylenetetrahydrofolate reductase C677T and schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 198-200, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-245334
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the methylenetetrahy drofolate reductase (MTHFR) C677T missense mutation and schizophrenia by linkage disequilibrium study.</p><p><b>METHODS</b>Linkage disequilibrium analys is was conducted bet ween MTHFR C677T and schizophrenia in 115 affected-sib-pair (105) and trios (10) families by XDT and MAPMAKER/SIBS soft system. The analyses were performed in different diagnostic categories and combined with the age of onset as well.</p><p><b>RESULTS</b>No positive results were found in the analysis in all the family in all the four diagnostic categories. Significant P values, which were P<0.05, P<0.01 respectively, were observed in the families with the affected individual's onset age less than 25 years in all the four diagnostic categories.</p><p><b>CONCLUSION</b>The missense mutation of MTHFR C677T or other gene structure around this mutation may be one of the susceptibility gene of schizophrenia.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
DNA
/
Nuclear Family
/
Linkage Disequilibrium
/
Family Health
/
Mutation, Missense
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Methylenetetrahydrofolate Reductase (NADPH2)
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Oxidoreductases Acting on CH-NH Group Donors
/
Gene Frequency
/
Genetics
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2002
Document type:
Article