The clinical features and natural history of post-transfusion hepatitis C / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 199-201, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-245710
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical features and natural history of post-transfusion hepatitis C (PTHC).</p><p><b>METHODS</b>Ninety-nine post-transfusion hepatitis C patients were analyzed using retrospective and prospective study and follow-up.</p><p><b>RESULTS</b>(1) Ninety-nine post-transfusion HCV patients were infected during 1989-1994, mostly between 1990-1992. (2) Ninety patients were diagnosed as chronic hepatitis C, and 9 as hepatic cirrhosis (period of compensation). (3) The intervals between their transfusions and their initial diagnoses of PTHC were 7.4+/-6.6 years in all 99 patients, and the intervals in 9 cirrhosis patients were 12.7+/-5.8 years. (4) Among 63 male patients, 59 cases were chronic hepatitis C and 4 were cirrhosis while among 36 female patients, 31 were chronic hepatitis C and 5 were cirrhosis. There was no significant difference of the ratio for hepatitis C and cirrhosis between the male and female patients (P>0.05). (5) Repeat abnormal liver function occurred accompanied with a fluctuation of ALT elevation in those patients with cirrhosis. (6) No patient developed hepatic carcinoma during the study period.</p><p><b>CONCLUSIONS</b>(1) The possibility of HCV infection by transfusion has declined greatly since 1995 in Guangzhou. (2) Nine of the 99 (9.1%) chronic HCV-infected patients developed a compensated cirrhosis after 12.7+/-5.8 years. (3) For those PTHC patients with repeat abnormal liver functions, interferon combined with ribavirin is recommended to prevent the development of cirrhosis.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.3 End transmission of communicable diseases
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Hepatitis
/
Cirrhosis
/
Digestive System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Prospective Studies
/
Retrospective Studies
/
Follow-Up Studies
/
Hepatitis C
/
Diagnosis
/
Transfusion Reaction
/
Liver Cirrhosis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2006
Document type:
Article