Preparation of inclusion complex of paeonol and beta-cyclodextrin by sealed-control temperature method / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 218-221, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-246006
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>In the present study, using paeonol as model drug, a new sealed-control temperature method of preparing inclusion complex was developed, the effects of heating temperature, heating time, and crystallinity of beta-cyclodextrin (beta-CD) on formation of inclusion complex and release of the drug were investigated.</p><p><b>METHOD</b>A physical mixture of paeonol and beta-CD was sealed in a container, and heated at the desired temperature for the specified time. The inclusion complex of paeonol and beta-CD was confirmed by IR spectrum and powder X-ray diffraction.</p><p><b>RESULT</b>The results indicated that the inclusion complex formation of paeonol beta-CD by sealed-control temperature method was affected by heating temperature, heating time, and crystallinity of beta-CD. The inclusion complex was able to inhibit sublimation of paeonol, and dissolution rate of paeonol was increased when the paeonol was included by beta-CD.</p><p><b>CONCLUSION</b>Preparation of inclusion complex was simple and quick by sealed-control temperature method.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Acetophenones
/
Solubility
/
Spectrophotometry, Infrared
/
Temperature
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X-Ray Diffraction
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Chemistry
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Crystallization
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Beta-Cyclodextrins
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Drug Compounding
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Hot Temperature
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Document type:
Article