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Efficacy of peg interferon alpha-2a in combination with ribavirin in treatment of with hepatitis C cirrhosis patients / 中华实验和临床病毒学杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-246207
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical efficacy of PEG Interferon alpha-2a combined with ribavirin in treatment of with hepatitis C cirrhosis patients.</p><p><b>METHODS</b>21 patients with chronic hepatitis C cirrhosis (treated group) ,were treated with peg-IFNalpha-2a 135 -180 microg subcutaneously, 1 week,ribavirin tablets 800 -1000 mg/d,48 weeks of treatment and follow-up 24 weeks, 20 patients with Chronic hepatitis C (control group), were treated with peg-IFNalpha-2a 135 -180 microg subcutaneously, 1 week,ribavirin tablets 600 -1000 mg/d, 48 weeks of treatment, follow-up 24 weeks, comparison of rapid virological response (RVR) rates, early virologic response (EVR) rate, sustained virologic response (SVR) rate, adverse reactions was observed.</p><p><b>RESULTS</b>The differences of RVR, EVR, ETVR in two groups is not significant, but SVR in treatment group was lower (P < 0.05), and has a higher incidence bone marrow suppression and anemia (P < 0.05). Flu-like symptoms, hair loss, gastrointestinal reactions and other adverse reactions was no significant difference between the two groups.</p><p><b>CONCLUSION</b>The use of 135 microg peg-IFNalpha-2a and individual in low-dose ribavirin hepatitis C patients with cirrhosis is more security,could get a good early response, but sustained virologic response (SVR) rates is lower than hepatitis C patients. Blood, liver and kidney function should be closely observed during treatment process.</p>
Subject(s)
Full text: Available Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: WPRIM (Western Pacific) Main subject: Polyethylene Glycols / Ribavirin / Virology / Recombinant Proteins / Interferon-alpha / Hepatitis C, Chronic / Drug Therapy / Drug Therapy, Combination / Liver Cirrhosis Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2011 Document type: Article
Full text: Available Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: WPRIM (Western Pacific) Main subject: Polyethylene Glycols / Ribavirin / Virology / Recombinant Proteins / Interferon-alpha / Hepatitis C, Chronic / Drug Therapy / Drug Therapy, Combination / Liver Cirrhosis Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2011 Document type: Article
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