Investigate the impact of hepatitis B virus infection on sperm DNA integrity / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>Investigated the impact of HBV infection on sperm DNA integrity and its applied significance.</p><p><b>METHODS</b>12 cases infertility male with HBV infection in patient group and 11 cases of normal male without HBV infection in the control group were by SCD and CASA.</p><p><b>RESULTS</b>The DFI in the patient group was (23.4 +/- 10.2)%, while it was in the control group was (11.6 +/- 5.9)%. The difference of the DFI in these two groups was significantly, P < 0.01. The sperm concentration and forward motility (a + b) in the patient group were lower than that in the control group, P < 0.01. There were also significantly of the normal sperm and sperm activity between the two groups.</p><p><b>CONCLUSION</b>HBV infection not only affected the conventional semen parameters, but also caused serious damage on sperm DNA.</p>