Study on EB virus infection, LMP1 and Bcl-2 expression in lung cancer patients / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 277-279, 2011.
Article
in Zh
| WPRIM
| ID: wpr-246266
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the Epstein-Barr virus (EBV) infection, the expression of EBV latent membrane protein 1 ( LMPl) and oncogene bcl-2 in lung cancer patients.</p><p><b>METHODS</b>EBERI in 108 cases of lung cancer were detected with in situ hybridization. EBV positive and negative lung cancer tissues were analysed for the expression of LMP1 and Bcl-2 by immnohistochemistry. The average area (AA) and integral optical density (IA) of each sample was measured with the digital medical image analyzing system.</p><p><b>RESULTS</b>In 108 cases of lung cancer, 36 cases were EBER1 positive and 7 cases were LMP1 positive. The expression of Bcl-2 was higher in EBV positive lung cancer tissues than that in EBV negative. The AA value was 58014.23 +/- 6918.45 and 38156.22 +/- 4096.79, while the IA value was 11.00 +/- 1.48 and 8.03 +/- 0.78 respectively. No statistic difference was fund in the expression of Bcl-2 betwen LMP1 positive and negative lung cancer tisssues.</p><p><b>CONCLUSION</b>EBV infection in lung cancer increased the expression of bcl-2, which may play a role in the occurrence or development of lung cancer. The increased expression of Bcl-2 may not be induced by LMP1. The exact mechanism need further study.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Physiology
/
Virology
/
Gene Expression Regulation, Viral
/
Viral Matrix Proteins
/
Herpesvirus 4, Human
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Proto-Oncogene Proteins c-bcl-2
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Epstein-Barr Virus Infections
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Genetics
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Lung Neoplasms
Limits:
Adult
/
Aged
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2011
Document type:
Article