Oligodendrocyte and spinal cord injury / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1226-1229, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-246475
Responsible library:
WPRO
ABSTRACT
Spinal cord injury (SCI) is frequently companied by necrosis and apoptosis of oligodendrocytes (OLs), which contributes to demyelination of myelinated nerve fibers and their electrophysiological defects. This pathological demyelination often results in sensory or motor deficits. Here, we first focus on the microenvironment changes after SCI that cause OLs' death, then discuss the major mechanism of endogenous oligodendrocytogenesis and axonal remyelination, and finally summarize current therapies targeting OLs protection and replacement.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Spinal Cord
/
Spinal Cord Injuries
/
Therapeutics
/
Oligodendroglia
/
Cell Death
/
Apoptosis
/
Necrosis
/
Nerve Fibers, Myelinated
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2012
Document type:
Article