Research progress of abnormal phosphorylation of microtubule-associated tau protein and of the targeted inhibition of the phosphorylation / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 788-792, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-246558
Responsible library:
WPRO
ABSTRACT
Progressive dementia is described as the first and most prominent symptom of Alzheimer's disease (AD), and hyperphosphorylation of microtubule associated Tau protein (MAPT) plays a key role in neurodegeneration and neuronal dysfunction in AD and other neurodegenerative diseases. This paper reviews several protein kinases and phosphatases which can phosphorylate/dephosphorylate Tau protein, and evaluates a therapeutic strategy based on targeted inhibition of Tau kinases and activation of Tau phosphatases.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Physiology
/
Protein Kinases
/
Chemistry
/
Tau Proteins
/
Phosphoric Monoester Hydrolases
/
Neurodegenerative Diseases
/
Glycogen Synthase Kinase 3
/
Alzheimer Disease
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2012
Document type:
Article