Research progress on MKP-1 in tumor drug resistance / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 111-116, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-247174
Responsible library:
WPRO
ABSTRACT
The main obstacle for chemotherapy is tumor drug resistance. Studying the mechanisms of drug resistance and reversing drug resistance is the key to improve the effectiveness of chemotherapy. It has been reported that MKP-1 plays an important role in tumor drug resistance. MKP-1, as a negative regulator of MAPKs, is involved in the MAPKs mediated drug resistance and is regulated by ERK and p38 signaling pathways.However, the relationship between MKP-1 and other drug resistance-related signaling pathways is not clear and requires further investigation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Signal Transduction
/
Drug Resistance, Neoplasm
/
Dual Specificity Phosphatase 1
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2012
Document type:
Article