Study on the distribution of Y chromosome haplogroups in Sichuan Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 261-265, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-247339
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution characteristics of Y chromosome haplogroups in Sichuan Han population.</p><p><b>METHODS</b>Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), denatured high performance liquid chromatography (DHPLC) and DNA sequencing methods, 18 Y-chromosome bialletic markers were detected to type Y chromosome haplogroups in 341 unselected men from Sichuan Han population.</p><p><b>RESULTS</b>A total of 14 haplogroups were observed, in which haplogroups H2 and H4 were identified for the first time in Sichuan population, and haplogroups H14 and N* were found firstly in Chinese. There was a significant frequency difference of Y haplogroups between Sichuan Han population and Southern Han population.</p><p><b>CONCLUSION</b>More comprehensive frequency distribution data of Y chromosome haplogroups are obtained in Sichuan Han population, which would be helpful for understanding the association of Y chromosome background and the susceptibility to male specific diseases such as spermatogenic failure, prostate cancer, testical cancer and so on in present population.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Haplotypes
/
Ethnicity
/
China
/
Genetic Predisposition to Disease
/
Chromosomes, Human, Y
/
Asian People
/
Electrophoresis, Polyacrylamide Gel
/
Ethnology
/
Genetics
/
Mutation
Type of study:
Prognostic study
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2007
Document type:
Article