The effects of diethylene glycol on liver function / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 217-221, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-247554
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the hepatotoxic effects of accidental intravenous diethylene glycol (DEG.) poisoning in patients with liver disease.</p><p><b>METHODS</b>Clinical data and liver function results were obtained from 64 patients with liver diseases who had been accidentally treated with diethyl glycol-contaminated agent and 45 cases with hepatorenal failure. The hepatotoxic effects of diethylene glycol DEG on the patients with liver diseases were assessed by multivariable logistical regression analysis.</p><p><b>RESULTS</b>Of the 64 cases with liver diseases, 15 cases (23.4%) developed toxic presentations following the accidental administration of DEG. All affected cases were male. Twelve of the 15 poisoned patients (80%), died within 7 days of exposure to DEG. The most common clinical manifestations included kidney damage, renal failure, metabolic acidosis, and nerve system disturbances. The intravenous administration of DEG resulted in only mild liver function impairment. In terms of risk factors, both gender (r = 4.266, P less than 0.05) and the severity of jaundice prior to DEG administration were related to the occurrence of toxin-induced renal failure (r = 7.640, P less than 0.01).</p><p><b>CONCLUSIONS</b>DEG may worsen liver damage in patients with liver diseases.</p>
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Zoonoses
Database:
WPRIM (Western Pacific)
Main subject:
Poisoning
/
Logistic Models
/
Drug Therapy
/
Ethylene Glycols
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Chemical and Drug Induced Liver Injury
/
Liver Diseases
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Medication Errors
Type of study:
Prognostic study
/
Risk factors
Limits:
Adolescent
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Adult
/
Aged
/
Child
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Child, preschool
/
Female
/
Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2010
Document type:
Article