Relationship of porphyromonas gingivalis PG0717 gene with chronic periodontitis / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 648-651, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-248335
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The aim of the present study was to investigate PG0717 gene of Porphyromonas gingivalis (P. gingivalis) in subgingival plaque of the chronic periodontitis patients and periodontal healthy subjects, and to find out the relationship of detection rate of PG0717 and periodontal clinical parameters.</p><p><b>METHODS</b>A total of 540 subgingival plaque samples were collected from 180 subjects including chronic periodontitis (CP) patients (n=90) and periodontal healthy individuals (n=90). The periodontal clinical parameters including probing depth (PD), clinical attachment loss (CAL), and bleeding on probing (BOP) were estimated by Florida probe. The extracted DNA samples of P. gingivalis positive was amplified with the sequence specific primers designed to obtain the PG0717 gene.</p><p><b>RESULTS</b>In subgingival plaque of P.gingivalis positive, the detection rate of PG0717 in CP group was significantly higher than that in periodontal healthy subjects (56.22% versus 41.27%, chi2=4.50, P<0.05). The detection rate of PG0717 in CP group showed the increasing tendency in accordance with the depth of PD and CAL. A higher detection rate of PG0717 was observed in the sites of BOP positive than that in BOP negative (57.73% versus 14.29%, chi2=42.01, P<0.01).</p><p><b>CONCLUSION</b>The findings suggest that the PG0717 gene may influence the virulence of P. gingivalis.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Porphyromonas gingivalis
/
Dental Plaque
/
Chronic Periodontitis
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2008
Document type:
Article