Drop out of antiretroviral therapy in people living with AIDS/HIV and related factors in Nanjing and Yuncheng / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To understand the incidence of drop out of antiretroviral therapy (ART) in people living with AIDS/HIV and related factors in Nanjing, Jiangsu province, and Yuncheng, Shanxi province.</p><p><b>METHODS</b>Retrospective cohort analysis was conducted. The cumulative incidence curves of drop out of ART, mortality and drug withdrawal were drawn with Kaplan-Meier method. The related factors were identified with Cox proportional hazards regression model.</p><p><b>RESULTS</b>A total of 1 006 patients were included in Yuncheng, the median length of ART follow-up was 49.59 months (QR 20.02-92.84), and 976 patients were included in Nanjing, the median length of ART follow-up was 19.93 months (QR 11.48-34.07). The cumulative incidence of drop out of ART at 3 months, 6 months, 1 year, 2 years, 4 years, 8 years after ART was 8.19%, 9.23%, 11.08%, 13.75%, 17.74%, 27.66% in Yuncheng, and 3.01%, 5.17%, 7.47%, 10.97%, 17.45%, 28.72% in Nanjing respectively. Age, marital status, infection route, baseline CD4 cell count, the clinical stage classified by WHO at the end of the observation were correlated with the drop out of ART.</p><p><b>CONCLUSION</b>In order to reduce the drop out of ART among people living with AIDS/HIV, it is necessary to conduct effective interventions targeting the patients with young age, the patients who divorced/widowed, the patients who were intravenous drug users, the patients with higher CD4 cell count at the beginning of ART and clinical stage III or IV at the end of the follow-up and increase the coverage of HIV test.</p>