Clinical outcomes and economic analysis of two ovulation induction protocols in patients undergoing repeated IVF/ICSI cycles / 南方医科大学学报
Journal of Southern Medical University
; (12): 563-567, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-249407
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the clinical outcomes and cost-effectiveness of luteal phase down-regulation with gonadotrophin-releasing hormone (GnRH) agonist protocol and GnRH antagonist protocol in patients undergoing repeated in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) cycles.</p><p><b>METHODS</b>A retrospective analysis of clinical outcomes and costs was conducted among 198 patients undergoing repeated IVF-ICSI cycles, including 109 receiving luteal phase down-regulation with GnRH agonist protocol (group A) and 89 receiving GnRH antagonist protocol (group B). The numbers of oocytes retrieved and good embryos, clinical pregnancy rate, abortion rate, the live birth rate, mean total cost, and the cost-effective ratio were compared between the two groups.</p><p><b>RESULTS</b>In patients undergoing repeated IVF-ICSI cycles, the two protocols produced no significant differences in the number of good embryos, clinical pregnancy rate, abortion rate, or twin pregnancy rate. Compared with group B, group A had better clinical outcomes though this difference was not statistically significant. The number of retrieved oocytes was significantly greater and live birth rate significantly higher in group A than in group B (9.13=4.98 vs 7.11=4.74, and 20.2% vs 9.0%, respectively). Compared with group B, group A had higher mean total cost per cycle but lower costs for each oocyte retrieved (2729.11 vs 3038.60 RMB yuan), each good embryo (8867.19 vs 9644.85 RMB yuan), each clinical pregnancy (77598.06 vs 96139.85 RMB yuan).</p><p><b>CONCLUSION</b>For patients undergoing repeated IVF/ICSI cycle, luteal phase down-regulation with GnRH agonist protocol produces good clinical outcomes with also good cost-effectiveness in spite an unsatisfactory ovarian reserve.</p>
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 4: Health financing
Database:
WPRIM (Western Pacific)
Main subject:
Ovulation Induction
/
Retrospective Studies
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Pregnancy Rate
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Costs and Cost Analysis
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Economics
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Methods
Type of study:
Practice guideline
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Health economic evaluation
/
Observational study
Aspects:
Social determinants of health
Limits:
Adult
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Female
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Humans
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Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Document type:
Article