The Effect of Isoflurane or Propofol on Hepatic Transaminase in Healthy Hepatitis B Carrier Patients / 대한마취과학회지
Korean Journal of Anesthesiology
; : 662-666, 2000.
Article
in Ko
| WPRIM
| ID: wpr-24945
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Isoflurane or propofol has been known to have a low potential for hepatotoxicity. The purpose of this study is to evaluate the effect of isoflurane or propofol on hepatic transaminase in healthy hepatitis B carrier patients. METHODS: Forty-six patients who were healthy hepatitis B carriers were studied following an orthopedic surgery. The patients were randomly assigned to Group I (n = 22) who received isoflurane, or group P (n = 24) who received propofol. The plasma concentrations of aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured on the day before the operation, and 1, 3, and 7 days after the operation. RESULTS: The plasma concentrations of AST were not changed significantly until the 7th day post-operatively in both groups, and there were no significant differences between the two groups. The plasma concentrations of ALT were significantly decreased at 1 and 3 days postoperatively (P < 0.05) in both groups. However, it recovered to baseline concentrations at 7 days postoperatively. There were no significant differences between the two groups. CONCLSIONS: The use of isoflurane or propofol does not increase the plasma concentrations of hepatic transaminase in Hepatitis B carrier patients after an operation.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Orthopedics
/
Plasma
/
Aspartate Aminotransferases
/
Propofol
/
Alanine Transaminase
/
Hepatitis
/
Hepatitis B
/
Isoflurane
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
2000
Document type:
Article