Melanocortin-4 receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 662-665, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-250362
Responsible library:
WPRO
ABSTRACT
Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain, but the possible mechanism is poorly understood. Using a melanocortin-4 receptor (MC4R)-green fluorescent protein (GFP) reporter knockin mouse, we showed that a large number of MC4R-GFP-positive neurons were expressed in the cuneiform nucleus. Immunofluorescence revealed that approximately 40%-50% of MC4R-GFP-positive neurons expressed mu opioid receptors, indicating that they were opioidergic signaling. Our findings support the hypothesis that MC4R expression in the cuneiform nucleus is involved in the modulation of opioidergic signaling.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Recombinant Fusion Proteins
/
Mice, Transgenic
/
Signal Transduction
/
Gene Expression Regulation
/
Genes, Reporter
/
Receptors, Opioid, mu
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Cell Biology
/
Receptor, Melanocortin, Type 4
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Green Fluorescent Proteins
/
Gene Knock-In Techniques
Limits:
Animals
Language:
English
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2015
Document type:
Article