Progress in the study of tubulin inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 1078-1088, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-250568
Responsible library:
WPRO
ABSTRACT
Microtubule is one of the key components of the cytoskeleton and plays an important role in the maintenance of cell shape and the process of signal transduction and mitosis. Due to the extreme importance of microtubule in the process of mitosis, tubulin becomes one of the most important targets for development of new anticancer drugs and tubulin inhibitors are used for the treatment of cancer nowadays. These inhibitors have antitumor activity by inhibiting or promoting the assembly of tubulin to microtubules and interfering the process of cell mitosis. This review summarized the research progress of the tubulin inhibitors, especially the introduction of the tubulin inhibitors of pharmacological activities and the progress of clinical research. Also, the development trend of these inhibitors is discussed.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Stilbenes
/
Structure-Activity Relationship
/
Tubulin
/
Molecular Structure
/
Chemistry
/
Drug Therapy
/
Tubulin Modulators
/
Metabolism
/
Microtubules
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Document type:
Article