The function of protein kinase C in myocardial fibrosis / 药学学报
Acta Pharmaceutica Sinica
; (12): 1467-1471, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-250608
Responsible library:
WPRO
ABSTRACT
Myocardial fibrosis is the common results of the development of a variety of heart diseases which leads to extracellular matrix protein metabolic disorders and causes cardiac remodeling owing to cardiac fibroblasts proliferation, eventually results in malignant arrhythmia, heart failure, and even the occurrence of sudden cardiac death. Effective inhibition of myocardial remodeling could prevent the occurrence of sudden death. To know the protein kinase C (PKC) effective mechanism of regulation on myocardial fibrosis, a new therapeutic target for reversing myocardial remodeling might be provided.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Fibrosis
/
Protein Kinase C
/
Classification
/
Cardiomegaly
/
Ventricular Remodeling
/
Matrix Metalloproteinase 9
/
Indoles
/
Maleimides
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Document type:
Article