Development and validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products / 药学学报
Acta Pharmaceutica Sinica
; (12): 347-352, 2010.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-250651
Responsible library:
WPRO
ABSTRACT
An HPLC-UV method has been developed for the determination of valibose, miglitol, voglibose and acarbose, the four anti-diabetic drugs. The separation was accomplished successfully by using reversed phase chromatography (Prevail carbohydrate column, 250 mm x 4.6 mm, 5 microm) with a gradient acetonitrile-phosphate buffer solution (pH 8.0) at a wavelength of 210 nm. Furthermore, the method of a high-performance liquid chromatography coupled with ESI-MS in positive ionization mode has been established. These two methods were successfully applied to the assay and qualitative detection of four alpha-glucosidase inhibitors in the potential counterfeit anti-diabetic drugs.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Spectrophotometry, Ultraviolet
/
Chemistry
/
Chromatography, High Pressure Liquid
/
1-Deoxynojirimycin
/
Acarbose
/
Spectrometry, Mass, Electrospray Ionization
/
Alpha-Glucosidases
/
Chromatography, Reverse-Phase
/
Glycoside Hydrolase Inhibitors
/
Hypoglycemic Agents
Type of study:
Qualitative research
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Document type:
Article
