Studies on the formation mechanism of alginate-chitosan microcapsule and its drug-loading and release properties on macromolecular drug / 药学学报
Acta Pharmaceutica Sinica
; (12): 380-383, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-251080
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the formation mechanism, macromolecular drug loading capacity and release property of alginate-chitosan microcapsules (ACM).</p><p><b>METHODS</b>ACM was prepared by emulsification-gelation method and its formation mechanism was studied by DSC analysis. Using bovine serum albumin (BSA) as model drug, the drug loading and release properties of the microcapsules on macromolecular drug were investigated.</p><p><b>RESULTS</b>The results of DSC analysis showed that there is electrostatic interaction between materials encapsulated in the microcapsule. With the increase of BSA microcapsule ratio, the BSA loading percentage rose from 9.20% to 35.08%; and with the ascent of chitosan (CTS) concentration, the BSA loading percentage increased from 30.29% to 38.12%. The BSA microcapsules whowed a two-phase release in both 0.1 mol.L-1 HCl and phosphate buffer saline (pH 7.4). With the increase of CTS concentration, the BSA release more and more slowly in 0.1 mol.L-1 HCl.</p><p><b>CONCLUSION</b>Spheric and well-dispersed alginate-chitosan microcapsules were prepared. The microcapsule showed good loading capacity to BSA as well as sustained release to a certain degree.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Biopolymers
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Calorimetry, Differential Scanning
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Serum Albumin, Bovine
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Capsules
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Drug Carriers
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Chemistry
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Chitin
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Technology, Pharmaceutical
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Drug Delivery Systems
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Delayed-Action Preparations
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Document type:
Article