Continuous in situ monitoring of the dissolution rate of solid pharmaceutical preparations using a multiple channel fiber-optic chemical sensor / 药学学报
Acta Pharmaceutica Sinica
; (12): 294-297, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-251120
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To study the dissolution rate of solid pharmaceutical preparation on-line, a multiple channel fiber-optic chemical sensor based on fluorescence multiple quenching (FOCSMQ) without filtering and sampling was made.</p><p><b>METHODS</b>Using the multiple channel FOCSMQ linked with computer, the dissolution rates of ofloxacin tablets, metronidazole tablets and nitrofurantoin tablets were monitored continuously on-line. The instrument can give the sample data, display the real time curve and calculate the T1/2 and td automatically. A computer was used to select the best function from five common fitting models to fit the dissolution curve.</p><p><b>RESULTS</b>The average recoveries of the FOCSMQ method were 97.4%-104.4%, 97.4%-103.8% and 96.6%-102.1%. The RSDs (n = 6) of within-day and between-day were less than 5%. The parameters of the dissolution and all results of measurement using the instrument have no significant difference compared with the Chinese Pharmacopoeia (ChP) (2000) method and the United States Pharmacopoeia (USP) (23) method (P > 0.05). It does not need sampling and dilution, and never contaminate sample. It can shorten time of the experiment.</p><p><b>CONCLUSION</b>The method is simple, rapid and reliable.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Solubility
/
Tablets
/
Transducers
/
Ofloxacin
/
Chemistry
/
Chemistry, Pharmaceutical
/
Optical Fibers
/
Fiber Optic Technology
/
Methods
/
Metronidazole
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Document type:
Article