Design, synthesis and anti-platelet aggregation activities of ligustrazine-tetrahydroisoquinoline derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 326-331, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-251776
Responsible library:
WPRO
ABSTRACT
Abstract Fifteen novel ligustrazine-tetrahydroisoquinoline derivatives were designed and synthesized according to the association principle of pharmaceutical chemistry. The structures were identified by IR, NMR and ESI-MS. The inhibitory activities of platelet aggregation induced by ADP and AA have been measured by Bron method. Preliminary pharmacological results showed that compounds 7g, 7h and 7n had potent inhibitory activity against platelet aggregation induced by AA, and the compound 7o showed significant inhibitory activity against platelet aggregation induced by ADP.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pyrazines
/
Platelet Aggregation Inhibitors
/
Drug Design
/
Chemistry
/
Platelet Aggregation
/
Tetrahydroisoquinolines
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Document type:
Article