Research progress of p70 ribosomal protein S6 kinase inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 261-271, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-251785
Responsible library:
WPRO
ABSTRACT
p70 ribosomal protein S6 kinase (p70S6K), an important member of AGC family, is a kind of multifunctional Ser/Thr kinases, which plays an important role in mTOR signaling cascade. The p70 ribosomal protein S6 kinase is closely associated with diverse cellular processes such as protein synthesis, mRNA processing, glucose homeostasis, cell growth and apoptosis. Recent studies have highlighted the important role of S6K in cancer, which arose interests of scientific researchers for the design and discovery of anti-cancer agents. Herein, the mechanisms of S6K and available inhibitors are reviewed.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Chemistry
/
Ribosomal Protein S6 Kinases, 70-kDa
/
Protein Kinase Inhibitors
/
TOR Serine-Threonine Kinases
/
Metabolism
/
Antineoplastic Agents
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Document type:
Article