Outcomes of locally advanced prostate cancer: a single institution study of 209 patients in Japan / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 555-561, 2006.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-253803
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the outcomes for Asian populations with locally advanced/clinical stage III prostate cancer (PCa) treated with currently prevailing modalities.</p><p><b>METHODS</b>We reviewed the record of 209 patients with clinical stage III PCa, who were treated at Niigata Cancer Center Hospital between 1992 and 2003. Treatment options included hormone therapy-combined radical prostatectomy (RP+HT), hormone therapy-combined external beam irradiation (EBRT+HT) and primary hormone therapy (PHT).</p><p><b>RESULTS</b>The 5- and 10-year overall survival rates were 80.3% and 46.1% in all cohorts, respectively. The survival rates were 87.3% and 66.5% in the RP+HT group, 94.9% and 70.0% in the EBRT+HT group and 66.1% and 17.2% in the PHT group, respectively. A significant survival advantage was found in the EBRT+HT group compared with that in the PHT group (P < 0.0001). Also, the RP+HT group had better survival than the PHT group (P = 0.0107). The 5- and 10-year disease-specific survival rates for all cases were 92.5% and 80.0%, respectively. They were 93.8% and 71.4% in the RP+HT group, 96.6% and 93.6% in the EBRT+HT group and 88.6% and 62.3% in the PHT group, respectively. A survival advantage was found in the EBRT+HT group compared with the PHT group (P = 0.029). No significant difference was found in disease-specific survival between the EBRT+HT and RP+HT groups or between the RP+HT and PHT groups.</p><p><b>CONCLUSION</b>Although our findings indicate that radiotherapy plus HT has a survival advantage in this stage of PCa, we recommend therapies that take into account the patients'social and medical conditions for Asian men with clinical stage III PCa.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Prostate Cancer
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostatectomy
/
Prostatic Neoplasms
/
Radiotherapy
/
General Surgery
/
Time Factors
/
Blood
/
Survival Rate
/
Retrospective Studies
/
Follow-Up Studies
Type of study:
Observational study
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Journal of Andrology
Year:
2006
Document type:
Article