DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 183-187, 2006.
Article
in En
| WPRIM
| ID: wpr-253860
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To explore the possible effect of the deleted in azoospermia (DAZ) copy cluster deletion on spermatogenesis in the Chinese population, the deletion of the azoospermia factor c (AZFc) region was analyzed in 346 normozoospermic men.</p><p><b>METHODS</b>Three DAZ single nucleotide variant loci and seven AZFc-specific sequence-tagged sites were examined with polymerase chain reaction (PCR)-restriction fragment length polymorphism and routine PCR.</p><p><b>RESULTS</b>Five (1.4%) of the normozoospermic men were found to have deletion of gr/gr-DAZ1/DAZ2. None of the men were found to have b2/b4-entire DAZ deletion.</p><p><b>CONCLUSION</b>The presence of gr/gr-DAZ1/DAZ2 deletion in five men with normozoospermia suggests that this deletion per se may not be sufficient for spermatogenic impairment in Chinese men.</p>
Full text:
1
Database:
WPRIM
Main subject:
Oligospermia
/
Recombination, Genetic
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Spermatogenesis
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Polymorphism, Restriction Fragment Length
/
China
/
Sequence Tagged Sites
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RNA-Binding Proteins
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Gene Deletion
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Chromosomes, Human, Y
/
Asian People
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Asian Journal of Andrology
Year:
2006
Document type:
Article