The investigation of HEV epidemiology, inferior clinical infection and viral-toxemia in blood donors in Quzhou area / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 45-47, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-254145
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the infection of HEV in Quzhou area of Zhejiang Province.</p><p><b>METHODS</b>All sera from blood donors in the central blood bank of Quzhou from April 2006 to April 2007 were used. Anti-HEV IgG and anti-HEV IgM were measured by EIA. RT-PCR was also performed to the samples with positive anti-HEV IgM. Genotype and sequence homology were analyzed after sequencing.</p><p><b>RESULTS</b>The positive ratio of anti-HEV IgG was 40.60%, in which the male infection ratio was higher than the female significantly (43.09% VS 36.09%; chi2=22.6; P < 0.01). The infection ratio was increased with age. The positive ratio of anti-HEV IgM was 0.43%. The positive ratio of anti-HEV IgG and the titers of antibody were higher in the inferior clinical infectors with positive anti-HEV IgM than the negative ones (P < 0.05). Two samples were positive in HEV PCR among 21 samples with positive anti-HEV IgM. The toxemia ratio was 0.4% of all the donors. And the genotype of the two samples with toxemia were both HEV-IV.</p><p><b>CONCLUSION</b>The HEV infection was correlation with age and sex significantly and the infection occurred in the adults mainly in Quzhou area. HEV toxemia was not infrequency in the blood donors.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Toxemia
/
Virology
/
Blood Donors
/
Immunoglobulin G
/
Immunoglobulin M
/
China
/
Sex Factors
/
Epidemiology
/
Age Factors
/
Hepatitis E virus
Type of study:
Screening study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2008
Document type:
Article