Inducible nitric oxide synthase and brain hypoxic-ischemic brain damage / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 962-967, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-254157
Responsible library:
WPRO
ABSTRACT
Brain hypoxia-ischemia has been considered as critical factors in many human central nervous system diseases, including stroke and neonatal hypoxic-ischemic encephalopathy. In brain hypoxia-ischemia processes, inducible NO synthase (iNOS) is induced to produce excessive nitric oxide (NO) which leads to cascade reactions of inflammation and neuronal death, deteriorating primary brain injury. Inhibiting iNOS expression has opened new perspectives in the treatment of brain hypoxia-ischemia because iNOS inhibitor has been shown as a potent therapeutic agent. This reviews focus on recent research achievements regarding the relationship between iNOS and ischemic-hypoxic brain damage and the perspective of using iNOS inhibitors as therapeutic strategies for brain ischemic-hypoxic brain damage.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Hypoxia-Ischemia, Brain
/
Drug Therapy
/
Nitric Oxide Synthase Type II
/
Genetics
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2014
Document type:
Article