Structural analysis of 22 full-length hepatitis B virus genomes isolated from patients with hepatocellular carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 213-216, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-254339
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the characteristics of full-length Hepatitis B Virus (HBV) genomes isolated from patients with hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>The full-length HBV genomes from the serum of HBsAg positive HCC patients were amplified by PCR, and then sequenced and analyzed its structure.</p><p><b>RESULTS</b>Twenty-two full-length HBV DNAs were obtained from different patients of HCC. Phylogenetic analysis revealed that all HBV strains could be categorized into genotype B or C and serotype adr or adw2. Structural analysis showed that HBV obtained shared meaningful consensus mutations in B/T cell epitopes of surface and core antigens, transactivating domain of X protein and enhancer II/core promoter regions as compared to standard strains.</p><p><b>CONCLUSION</b>Genotype and gene mutation of HBV may be closely correlated with the carcinogenesis of HBV-related hepatocellular carcinoma.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Virology
/
DNA, Viral
/
Trans-Activators
/
Hepatitis B virus
/
Promoter Regions, Genetic
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Genome, Viral
/
Cloning, Molecular
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Carcinoma, Hepatocellular
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Allergy and Immunology
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2004
Document type:
Article