CREB-regulated transcription coactivator 1: important roles in neurodegenerative disorders / 生理学报
Acta Physiologica Sinica
; (6): 155-162, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-255962
Responsible library:
WPRO
ABSTRACT
The cAMP-responsive element binding protein (CREB)-regulated transcription coactivator, CRTC (also known as transducer of regulated CREB, TORC), is identified as a potent modulator of cAMP response element (CRE)-driven gene transcription. The CRTC family consists of three members (CRTC1-3), among which the CRTC1 shows the highest expression in the brain. Several studies have demonstrated that the CRTC1 plays critical roles in neuronal dendritic growth, long-term synaptic plasticity, memory consolidation and reconsolidation etc., whereas dysfunction of CRTC1 is mainly involved in neurodegenerative disorders. In light of these findings, we aim to review recent research reports that indicate the CRTC1 dysfunction and its underlying mechanisms in the neurodegenerative disorders.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Transcription Factors
/
Brain
/
Neurodegenerative Diseases
/
Dendrites
/
Neuronal Plasticity
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2015
Document type:
Article