Effect of Spatholobus suberectus on the bone marrow cells and related cytokines of mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 352-355, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-256355
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Spatholobus suberectus on proliferation and the hematonic mechanism.</p><p><b>METHOD</b>The techniques of culture of hematopoietic cell and hematopoietic growth factor (HGF) assay were used.</p><p><b>RESULT</b>Spatholobus suberectus could obviously promote the proliferation of bone marrow cells in healthy and anaemic mice. The culture media of spleen cell, macrophage, lung and skeletal muscle treated with S. suberectus had much stronger stimulating effects on hematopoietic cells.</p><p><b>CONCLUSION</b>S. suberectus may enhance hematopoiesis by directly or indirectly stimulating stroma cell in hematopoietic inductive microenvironment and muscle tissue to secrete some HGF (Epo, GM-CSF, IL, and MK-CSF). This is one of the biological mechanisms for hematonic effect of S. suberectus.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Bone Marrow Cells
/
Drugs, Chinese Herbal
/
Chemistry
/
Colony-Stimulating Factors
/
Plant Stems
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Cell Biology
/
Cell Proliferation
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2004
Document type:
Article