Recent advances in the quantification of drug metabolizing enzymes and transporters by proteomic approach / 药学学报
Acta Pharmaceutica Sinica
; (12): 668-674, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-257085
Responsible library:
WPRO
ABSTRACT
With the advance of drug development and research techniques, the drug metabolic processes and mechanism can be more deeply achieved. As the drug metabolism and pharmacokinetics process are mediated by drug metabolizing enzymes and transporters, study of drug metabolizing enzymes and transporters has become an important part for drug development. The traditional immunoassays with low sensitivity and poor specificity can not reflect the accurate expression level of drug metabolizing enzymes and transporters. We now give a brief review on the quantitative study of drug metabolizing enzymes and transporters by mass spectrometry-based proteomic approach.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Membrane Transport Proteins
/
Mass Spectrometry
/
Pharmacokinetics
/
Inactivation, Metabolic
/
Chemistry
/
Proteomics
/
Enzymes
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Document type:
Article