Role of p66Shc gene in human longevity / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 686-690, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-257693
Responsible library:
WPRO
ABSTRACT
The p66Shc gene has emerged as a novel gerontogene affecting health and life during aging. In murine models of aging,a genetic deficiency of the p66Shc gene,which encodes a phosphotyrosine signal adapter protein,extends life span by 30%. p66Shc is a crucial regulator of reactive oxygen species levels and is involved in age-related dysfunctions. UP to now,oxidative stress has been recognized to be involved in human diseases such as high cholesterol,diabetes,and cardiovascular diseases. Further study on the role of p66Shc will facilitate the research of novel disease-targetted drugs and slow down or cure age-related pathologies.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Aging
/
Reactive Oxygen Species
/
Oxidative Stress
/
Shc Signaling Adaptor Proteins
/
Genetics
/
Longevity
/
Metabolism
Limits:
Animals
/
Humans
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2014
Document type:
Article