The use of recombinant activated factor VII for blood loss after cardiovascular surgery / 中华外科杂志
Chinese Journal of Surgery
; (12): 1497-1501, 2008.
Article
in Zh
| WPRIM
| ID: wpr-258335
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To describe the early experiences with rFVIIa in the management of bleeding after cardiovascular surgery.</p><p><b>METHODS</b>From May 2006 through December 2007, 16 patients received rFVIIa during or after surgery despite conventional medical therapy and transfusion of blood products. There were 15 male patients and 1 female patients, aged from 36 to 77 years old with a mean of 52 years old. The surgical procedures include aortic procedures for 8 cases, valve replacement for 6 cases, pulmonary thromboendarterectomy for 1 case and atrial septal defect repair for 1 case. The data of these patients were reviewed and the safety and efficacy of rFVIIa after cardiovascular surgery were evaluated.</p><p><b>RESULTS</b>rFVIIa was administered as a first dose of 27.6 to 54.5 microg/kg with a mean of 40.2 microg/kg. Six patients achieved hemostasis after the first dose. Nine patients received a second administration within 30 min, with a cumulative dose of 59.3 to 90.9 microg/kg, a mean of 80.3 microg/kg. Eight patients achieved hemostasis and 1 patient went to exploration. One patient received four doses of rFVIIa with a cumulative dose of 203.4 microg/kg and the bleeding stopped. Mean amount of chest drain loss and the amount of red blood cell, fresh frozen plasma, cryoprecipitate, and platelet transfusions decreased significantly after rFVIIa administration. The total amount of chest drain losses, transfusions of red blood cell and cryoprecipitate within 12 h postoperatively was positively correlated with the time from the end of bypass to administration of rFVIIa. No thromboembolic complications and other adverse reactions were noted.</p><p><b>CONCLUSIONS</b>The use of rFVIIa is associated with reduced blood loss, rapid improvement of coagulation variables, and decreased need for blood products. rFVIIa is safe and efficacious in the management of refractory postcardiotomy bleeding.</p>
Full text:
1
Database:
WPRIM
Main subject:
Cardiovascular Surgical Procedures
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Recombinant Proteins
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Coagulants
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Factor VIIa
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Retrospective Studies
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Postoperative Hemorrhage
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Therapeutic Uses
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Drug Therapy
Type of study:
Observational_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Surgery
Year:
2008
Document type:
Article